Endocrine Abstracts

Introduction: High levels of autoantibodies to glutamic acid decarboxylase (GAD-Ab) have been described in multiple conditions such as: stiff-man syndrome, type 1 diabetes mellitus, latent autoimmune diabetes in adults (LADA), patients with auto-immune polyglandular failure and etc. In addition, some of the patients with progressive cerebellar ataxia show high titer of GAD-Ab, it may play a critical role in its development, as these antibodies are involved in the pathogenesis ...

Introduction: Hypothyroidism is a clinical syndrome resulting from a deficiency of thyroid hormones, which in turn results in a generalized slowing down of metabolic processes. There are consistent reports demonstrating that many diseases, including the thyroid gland dysfunction are associated with changes of serum homocysteine (tHcy) level, with its genetic and epigenetic causes.Case report: In 2018 we reported 51 and 52-year-old sisters diagnosed with ...

Introduction: Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism results in thermolabile, reduced functioning enzyme and predicts hyperhomocisteinemia and altered DNA methylation. On the other hand, several studies indicated a higher plasma homocysteine (Hcy) levels in patients with primary hypothyroidism than in healthy, euthyroid individuals, including some experimental studies that indicated decreased MTHFR activity in hypothyroid patients. We cond...